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International Team Maps the Mouse Genome

NEW YORK, Aug. 4 - An international team of researchers today said it has mapped the mouse genome.


The researchers said the physical map, which contains 296 contigs of overlapping bacterial clones and 16,992 unique markers, provides a framework to assemble the whole genome-shotgun sequence data for the organism.


They said the BAC coverage, though "virtually complete," still has 275 gaps that exist in the clone map. To align the mouse contigs, the team used 51,486 human-mouse homology matches based on human and mouse sequences.


The work was performed by scientists at the Wellcome Trust Sanger Institute, in London; the Genome Sequencing Center at Washington University School of Medicine, in St. Louis; the Genome Sciences Centre at the British Columbia Cancer Agency; the Institute for Genome Research in Rockville, Md.; the Children's Hospital Oakland Research Institute, in California; the European Bioinformatics Institute; and the Department of Electrical Engineering at Washington University.


The study is published this week online in Nature.


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