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Industry Consortium Wins $2.5M from German Government to Develop Adenoviral siRNA Kinome Chip

NEW YORK, June 17 (GenomeWeb News) - ProQinase, the NMI Natural and Medical Sciences Institute, and Antibodies by Design, all based in Germany, have received a three-year, €2 million ($2.45 million) grant from the German government to develop an adenoviral siRNA kinome chip, the partners said today.


The chip will enable scientists to inhibit all human protein kinases in parallel by RNA interference.


Under the collaboration, Antibodies by Design, a division of Munich-based MorphoSys, will generate recombinant antibodies against up to 250 protein kinases. NMI, a non-profit contractor based at the Universityof T bingen, together with MorphoSys, will create shRNA vectors. ProQinase, a division of KTB Tumorforschungs GmbH at the TumorBiologyCenterin Freiburg, will use the antibodies to confirm deactivation of the protein kinases by the shRNA vectors. NMI will also combine all the components into a chip format.


NMI said it has filed for a patent protecting the production and use of the chip with the German Patent Office.

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