Skip to main content
Premium Trial:

Request an Annual Quote

Incyte, CV Therapeutics Expand Heart Disease Collaboration

NEW YORK, Aug 27 – Incyte and CV Therapeutics said Monday they had agreed to work together to study the role genes play in heart disease, expanding a joint research effort that began in 1998.

Under the terms of the new agreement, the companies, both of Palo Alto, Calif., said they would focus on pinpointing genes associated with atherosclerosis and coronary artery disease.

CV Therapeutics will be responsible for developing biological models for studying the genetic aspect of cardiovascular disease and will supply mRNA from the models to Incyte. In turn, Incyte will generate RNA expression data using its microarray technology.

"Our collaboration with Incyte has been successful in identifying new therapeutic targets such as the ABC1 gene and other undisclosed potential targets, and we look forward to continuing this relationship with our scientific colleagues," Louis Lange, CEO of CV Therapeutics, said in a statement. 

"We are committed to studying cardiovascular disease in a genome-wide fashion in order to identify and develop new targets," he added. 

Financial terms of the deal were not disclosed.

The companies said that under their previous collaboration they had made a number of discoveries, including determining the ABC1 protein’s role in pumping cholesterol out of cells. 

The Scan

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.

Analysis of Endogenous Parvoviral Elements Found Within Animal Genomes

Researchers at PLOS Biology have examined the coevolution of endogenous parvoviral elements and animal genomes to gain insight into using the viruses as gene therapy vectors.

Saliva Testing Can Reveal Mosaic CNVs Important in Intellectual Disability

An Australian team has compared the yield of chromosomal microarray testing of both blood and saliva samples for syndromic intellectual disability in the European Journal of Human Genetics.

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.