Skip to main content

The Importance of Acknowledgement

Premium

In Nature Reviews Cancer, Dana-Farber Cancer Institute researchers Andriy Marusyk, Vanessa Almendro, and Kornelia Polyak discuss the intra-tumor heterogeneity of cancer and the implications of this diversity for the development of therapies and diagnostics. "It has become exceedingly apparent that the utility of profiles based on the analysis of tumors en masse is limited by intra-tumor genetic and epigenetic heterogeneity, as characteristics of the most abundant cell type might not necessarily predict the properties of mixed populations," the authors write. In addition to the malignant cells, the tumor's microenvironment is also an important factor to take into consideration. "Abnormal tumor microenvironments can result in increased genomic instability, further diversifying tumor cell populations," they add.

This heterogeneity needs to be acknowledged and accounted for during the analysis of a primary tumor, Marusyk, Almendro, and Polyak say. And the interactions between malignant and stromal cells within a tumor also need to be taken into account when an evaluation is performed and possible therapeutics developed. Further, they write, "it is worth interrogating whether intra-tumor phenotypic heterogeneity is linked to clinically important aspects of primary human cancers, such as subtype, prognosis, risk of metastases and therapeutic resistance." Given the importance of non-genetic factors that contribute to phenotypic heterogeneity, they add, "it may be worth exploring the link between non-genetic phenotypic diversity and clinical outcomes." Only by recognizing the importance of intra-tumor heterogeneity will researchers be able to develop effective combination therapies and technologies that will allow for the interrogation and understanding of tumors, the authors write.

(HT: Derek Lowe at In the Pipeline)

The Scan

Call to Look Again

More than a dozen researchers penned a letter in Science saying a previous investigation into the origin of SARS-CoV-2 did not give theories equal consideration.

Not Always Trusted

In a new poll, slightly more than half of US adults have a great deal or quite a lot of trust in the Centers for Disease Control and Prevention, the Hill reports.

Identified Decades Later

A genetic genealogy approach has identified "Christy Crystal Creek," the New York Times reports.

Science Papers Report on Splicing Enhancer, Point of Care Test for Sexual Transmitted Disease

In Science this week: a novel RNA structural element that acts as a splicing enhancer, and more.