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Impending NHLBI RFA Will Support Development of Large-Scale Re-Sequencing Tools

NEW YORK (GenomeWeb News) — The National Heart Lung and Blood Institute next year plans to fund as many as six grants to develop and validate large-scale genome-wide targeted re-sequencing and DNA-capture technologies, NHLBI said Friday.
The technologies would “draw upon available massively parallel single-molecule DNA sequencing and region-specific DNA capture technologies” and would be aimed at lowering the cost of re-sequencing so that large numbers of genes and individual genomes could be re-sequenced more easily and effectively, the agency said.
“Recognition of the power of conventional re-sequencing of candidate genes to detect highly informative, low frequency disease alleles provides the motivation for finding more cost-effective approaches that would allow expansion of re-sequencing to large numbers of genes and individuals,” the agency said in its notice, which can be read here
“Recent advances in the development of single-molecule DNA sequencing technologies and efficient methods for capturing specific genomic segments are bringing the goal of large-scale targeted human genome re-sequencing in thousands of humans within reach,” it added.
The NHLBI said its ultimate goal is to apply these technologies to large numbers of DNA samples collected in NHLBI’s bank of well-phenotyped populations.
The institute said it plans to issue a request for applications for these grants some time in the late fall of 2007, and expects applications to be due in late winter of 2008. The awards will be disseminated in fiscal 2008, NHLBI said.

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