Skip to main content
Premium Trial:

Request an Annual Quote

I3C- HOLD

DO NOT POST – I WILL UPDATE AFTER 2-3:30PM PANEL-- KEN

SAN DIEGO, June 26 – The Interoperable Informatics Infrastructure Consortium (I3C) unveiled their first demonstration of a working protocol Tuesday at the BIO 2001 Conference.

The XML-driven format allows the exchange and analysis of sequence data across 10 different organizations’ products. I3C views the demonstration as a bridge to the next step of defining components needed for a more general open architecture.

Insert Quote

The demonstration began with a query issued via a LabBook interface to an IBM DiscoveryLink database server. Sequences of interest were retrieved by combining data from a National Cancer Institute dataset and the Ohio State Human Genome Data Base. The sequences were stored in XML flat-file format and then imported into the Incogen Visual Integrated Bioinformatics Environment. Analysis services, including TurboGenomics’TurboBLAST, Blackstone Technology Group’s SmartBlast, and TimeLogic’s Hidden-Markov-Model Search, were accessed via VIBE. The analysis results were stored in XML format and imported onto the LabBook Genomic XML Viewer for visualization. As a last step, the result files were submitted for additional analysis to the National Cancer Institute database.

I3C, currently with 47 participants, was proposed in February by Sun Microsystems, the Biotechnology Industry Organization, the National Cancer Institute, and several commercial bioinformatics vendors to support an industry-wide effort to develop an open platform for the life sciences. The collaboration now includes Affymetrix, AP Biotech, DoubleTwist, the European Bioinformatics Institute, Gene Logic, IBM, Incogen, Incyte, LabBook, Millenium Pharmaceuticals, the National Cancer Institute, Oracle, and the Whitehead Institute, among others.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.