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Horizon Discovery to Support Blueprint Medicines' Cancer Research Platform

NEW YORK (GenomeWeb News) – Horizon Discovery announced today a research service agreement to deploy its X-MAN isogenic cell lines in support of Blueprint Medicine's "New Targets" discovery platform.

Blueprint is based in Cambridge, Mass., and develops highly selective kinase inhibitors for genomically defined cancer subsets. Under the terms of the deal, Horizon will use its platform and expertise to screen certain Blueprint kinase inhibitor tool compounds on a panel of 26 X-MAN isogenic cell lines, in the process providing insights into "elucidating synthetic lethal interactions with approximately 100 kinase targets in various cancer subtypes."

Blueprint has developed a platform combining genomics expertise with a novel library of kinase inhibitors that allows the development of "potent, highly selective compounds to address clear genomic driver targets," Horizon said.

Financial and other terms were not disclosed.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.