When the mapping project was launched in October 2002, the consortium said it planned to complete a map of common patterns of genetic variation by September 2005. A first draft, with one million markers, is expected to be ready by the end of this month-eight months ahead of schedule.
The consortium said it now plans to build a HapMap roughly five times denser than the map to be produced under the original plan. The new map will use the genotyping capacity of Perlegen Sciences to test an additional 4.6 million single-nucleotide polymorphisms from publicly available databases, the International HapMap Consortium said.
The additional HapMap funding came from the Wellcome Trust, which provided $624,000; Genome Canada/Genome Quebec, which gave $260,000; Bristol-Myers Squibb and Pfizer, which donated $100,000 each; Perlegen Sciences, which is giving at least $1.2 million based on in-kind services; and the National Human Genome Research Institute, which pledged $1 million.