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GT s December 2000


GT’s December 2000 issue cover story asked if ABI’s MALDI TOF/TOF mass-spec instrument would be key to Celera’s success in proteomics. A year later, it’s still unclear whether the instrument will live up to its promised throughput.

Scott Patterson, who has since been appointed vice president for proteomics at Celera, has installed a platform that combines a liquid chromatography-based approach for separating proteins with the MALDI TOF/TOF. Patterson recently told ProteoMonitor editor John MacNeil: “I think we had targets and milestones which we set and we’re meeting those.” What exactly were those milestones? Patterson declines to say.

A feature article in the same issue asked, “What the Heck is Hyseq Up To?” The answer, in part, was “fighting a patent dispute with Affymetrix.” At the time, Hyseq chairman George Rathmann told GT that resolving that battle was on his short list. Looks like he can check that one off: In late October, Affy and Hyseq announced that they had dropped their weapons and, of all things, formed a joint venture. What’s more, it appears that Radoje Drmanac’s persistence paid off. The inventor of Hyseq’s sequencing by hybridization technology will now head up a spinoff, Callida Genomics, that will, among other things, attempt to commercialize a high-speed DNA sequencing chip.

The Scan

Rare Genetic Disease Partnership

A public-private partnership plans to speed the development of gene therapies for rare genetic diseases, Stat News writes.

Approval Sought for Alzheimer's Drug

The Wall Street Journal reports Eli Lilly has initiated a rolling submission to the US Food and Drug Administration to seek approval for its drug to treat Alzheimer's disease.

DNA Barcoding Paper Retracted

Science reports that a 2014 DNA barcoding paper was retracted after a co-author brought up data validity concerns.

Nature Papers Present Genomic Analysis of Bronze Age Mummies, Approach to Study Host-Pathogen Interactions

In Nature this week: analysis finds Tarim mummies had local genetic origin, and more.