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Grants from NCI

The National Cancer Institute has earmarked about 48 percent of its FY 2006 budget for extramural research projects, and not a small part of that amount is paid out to researchers active in the realm of systems biology. According to the NCI website, approximately 4,500 research project grants are awarded each year to nearly 600 institutions across the United States.

In order to compile the list of grants below, Genome Technology mined the NCI grants database using the search terms “genomics,” “proteomics,” and “RNAi.” We then refined the list to focus on the larger and more technology-focused of the grants. This list is not comprehensive and is meant only to provide a sample of the types of systems biology cancer research funded by NCI.


  Award Project Title PI Name
Calibrant Biosystems $825,331 Integrated Top-Down/Bottom-Up Comprehensive Proteomics Brian Balgley
  $776,388 Electronic Protein Transfer for Proteome Analysis Jesse Buch
California Institute of Technology $3,599,190 NanoSystems Biology Cancer Center James Heath
Children’s Hospital Boston $740,056 Genomic Analysis of Medulloblastomas Scott Pomeroy
Dana-Farber Cancer Institute $616,177 Integrated Interactome Mapping Marc Vidal
  $146,200 Genome Amplification Tolerant to Sample Degradation Mike Makrigiorgos
  $136,890 Integrated Functional Genomic Analyses of Melanoma Levi Garraway
Duke University $299,589 Oncogenic Gene Regulatory Networks Joseph Nevins
  $130,733 Clinico-Genomics for Improved Ovarian Cancer Treatment Jennifer Pittman
Fred Hutchinson Cancer Research Center $527,572 Affinity-Based Serum Proteomics: Breast and Ovarian Cancer Martin McIntosh
  $351,329 Protein Biomarkers of Cancer Risk in Older Persons Christopher Li
Harvard University $408,921 Structure and Mechanism of Base-Excision DNA Repair Gregory Verdine
Illumina $488,204 High-Throughput Methylation Profiling System Jian-Bing Fan
Johns Hopkins University $515,131 Mammalian Retrotransposition Jef Boeke
Ludwig Institute for Cancer Research $349,675 Transcription Factor Target Mapping in Mammalian Genome Bing Ren
Mayo Clinic College of Medicine $470,521 Ovarian Cancer Screening Using Comprehensive Proteomics David Muddiman
Medical College of Georgia, Augusta $333,508 Laser Capture Microscopy and 2D-DIGE: Cancer Proteomics William Dynan
Roswell Park Cancer Institute $304,291 Sites of Developmental & Tissue-specific DNA Methylation William Held
Scripps Research Institute $722,829 Using Viral Nanoparticles to Target Cancer Marianne Manchester
Sloan-Kettering Institute for Cancer Research $376,650 Replication of the SV40 Genome Thomas Kelly
University of California, Berkeley $3,414,027 Structural Cell Biology of DNA Repair Machines John Tainer
University of California, San Francisco $427,448 Microarray-Based Scanning of the Mouse Genome Donna Albertson
  $299,906 High-Resolution Genomic Analysis of Amplicon Structure Donna Albertson
University of Connecticut School of Medicine $443,242 A High-multiplexed Phosphotyrosine Profiling Assay Bruce Mayer
University of Illinois, Chicago $306,125 Cath B and muPAR siRNA Constructs Regressed Glioma Growth Jasti Rao
University of Pennsylvania $1,254,291 Examining Oligonucleotide Effects on Gene Expression Alan Gewirtz
University of Texas MD Anderson Cancer Center $1,503,348 Processing of Complex Lesions in the Mammalian Genome Randy Legerski
University of Wisconsin, Madison $350,542 Single Molecule Genome Analysis of Oligodendroglioma David Schwartz
Virginia Polytechnic Institute and State University $487,072 Comprehensive Analysis of Microarray Gene Expression Yue Wang
Whitehead Institute for Biomedical Research $1,211,603 Genomic Imprinting and the Cloning of Mice Rudolf Jaenisch
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