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The Good Fight

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My mother's friend died of breast cancer when I was in middle school. Mrs. LoRusso, as I always called her, was a fighter. She beat the disease once, and became an activist for breast cancer awareness. She appeared on The Phil Donahue Show and was featured in the New York Times, advocating for funding for studies and for health insurance companies to cover newer cancer treatments. After relapsing, she kept on fighting and even sought out experimental treatment — she took tamoxifen back in the early 1990s. But to no avail. I remember my mother and another friend sitting at the kitchen table trying to choose a reading for Mrs. LoRusso's funeral, something that spoke to her strength. In the end, they selected: "The time of my departure is at hand. I have fought the good fight; I have finished the race, I have kept the faith."

In this, our 100th issue of Genome Technology, we highlight the work of researchers who are trying to make that good fight easier. In our cover story, beginning on page 36, we spoke to researchers who are using all the tools at their disposal — bioinformatics, metabolomics, sequencing, and more — to better understand the basics of cancer, why people are susceptible to it, and to better treat the disease.

Elsewhere in this issue we branch out from cancer coverage. In our collaboration section, Matthew Dublin delves into the partnership between the Sanford-Burnham Institute and Duke University. Together, the two hope to develop better technologies for metabolomics research. For a feature article, Tracy Vence looks into the proteomic tools being used to study proteins and find biomarkers.

A fresh addition to the GT team is Christie Rizk. You'll see her byline in the Markers section where she reports on genes tied to heart disease risk, as well as ones linked to a risk of alcohol dependency. You can also see blog posts she has written at The Daily Scan.

The Genome Technology staff would like to dedicate this issue to the memory of Mrs. LoRusso, as well as of Nasrallah and Reine Rizk, Christie's grandparents.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.