Genomics stocks closed sharply lower on Wednesday as the biotech sector tumbled for a second day due to profit-taking following the long holiday weekend, analysts said.

Celera Genomics (NYSE: CRA) closed at 100 7/16, down 4 1/16, or 3.9 percent, following a 7 percent drop on Tuesday. Incyte Genomics (Nasdaq: INCY) ended the session down 2 1/16, or 5.4 percent, at 36 1/2 following a 4.2 percent decline the previous day. And Affymetrix (Nasdaq: AFFX) shed 4 15/16, or 6.6 percent, to close at 70 on the heels of a 5.1 percent decline on Tuesday.

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