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Genome Technology s Peer Review: A Weekly Forum of Recently Published Journal Articles: Mar 22, 2005

NEW YORK, March 22 (GenomeWeb News) - The following is a description of a recently published research paper recommended by a scientist involved in integrated biology. The recommender, Emanuel Petricoin, is co-director of the FDA/NIH Proteomics Initiative until April 1, when he joins the faculty of GeorgeMasonUniversity.

 

For a complete list of recommended papers, read Genome Technology, a GenomeWeb News sister publication.


Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells

Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud O, Gjertsen BT, Nolan GP. Cell. 2004 Jul 23;118(2):217-228.

 

"In this Cell paper, lead author Garry Nolan at StanfordUniversityand his co-authors used multiparameter flow cytometry to monitor phospho-protein responses to environmental cues in acute myeloid leukemia at the single cell level. By exposing cancer cell signaling networks to potentiating inputs, rather than relying upon the basal levels of protein phosphorylation alone, the authors were able to discern unique cancer network profiles that correlated with genetics and disease outcome.

 

"Strikingly, the authors write, individual cancers manifested multiple cell subsets with unique network profiles, reflecting cancer heterogeneity at the level of signaling response. The results show a dramatic remodeling of signaling networks in cancer cells. Thus, single cell measurements of phospho-protein responses reveal shifts in signaling potential of a phospho-protein network, allowing for categorizing of cell network phenotypes by multidimensional molecular profiles of signaling, they conclude."

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.