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Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells
Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud O, Gjertsen BT, Nolan GP. Cell. 2004 Jul 23;118(2):217-228.
"In this Cell paper, lead author Garry Nolan at
"Strikingly, the authors write, individual cancers manifested multiple cell subsets with unique network profiles, reflecting cancer heterogeneity at the level of signaling response. The results show a dramatic remodeling of signaling networks in cancer cells. Thus, single cell measurements of phospho-protein responses reveal shifts in signaling potential of a phospho-protein network, allowing for categorizing of cell network phenotypes by multidimensional molecular profiles of signaling, they conclude."