Skip to main content
Premium Trial:

Request an Annual Quote

Genome Technology s Peer Review: A Weekly Forum of Recently Published Journal Articles: Feb 8, 2005

Following is a description of a recently published research paper recommended by a scientist involved in integrated biology. The recommender, Dick McCombie, is at Cold Spring Harbor Laboratory. This installment was reported and written by Meredith Salisbury, Genome Technology editor.

 

For a complete list of recommended papers, read  Genome Technology, a GenomeWeb News sister publication.


"Transcriptional regulatory code of a eukaryotic genome," Christopher Harbison, Benjamin Gordon, Tong Ihn Lee, Nicola Rinaldi, Kenzie MacIsaac, Timothy Danford, Nancy Hannett, Jean-Bosco Tagne, David Reynolds, Jane Yoo, Ezra Jennings, Julia Zeitlinger, Dmitry Pokholok, Manolis Kellis, Alex Rolfe, Ken Takusagawa, Eric Lander, David Gifford, Ernest Fraenkel, and Richard Young. Nature. 2004; 431 (02 Sept): 99-104.

 

The authors report having used the sequence elements bound by regulators in certain circumstances and conserved among yeast strains to construct a map of the transcriptional regulatory code of yeast. They note that comparative genomics has been used to find potential cis-regulatory sequences in the yeast genome based on phylogenetic conservation, but that such studies remain inconclusive as to whether and when transcriptional regulators occupy the discovered binding sites. The paper includes discussion of "the organization of regulatory elements in promoters and the environment-dependent use of these elements by regulators," according to the abstract. Authors add that "environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators."

 

Dick McCombie recommends this paper for being one of the first real looks at genome-wide regulation of transcription and transcription-factor binding in a eukaryotic organism.

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.