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Genome Technology s Peer Review: A Weekly Forum of Recently Published Journal Articles: Jun 14, 2005

NEW YORK, June 14 (GenomeWeb News) - Following is a description of two recently published research papers recommended by a scientist involved in integrated biology. The recommender, PJ Utz, is an assistant professor of medicine in the Division of Rheumatology and Immunology,
Stanford University School of Medicine.


For a complete list of recommended papers, read Genome Technology, a GenomeWeb News sister publication.


Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. McClain M, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA. Nature Medicine 11, 85-89 (2004).


First published online in Nature Medicine last December, this paper by Judith James of the Oklahoma University Health Sciences Center et. al investigates the origins of autoimmunity in systemic lupus erthematosus (SLE) by attempting to identify the environmental agents that could potentially incite autoimmunity. Using peptide arrays, the authors identified the initial autoantigenic epitope for some lupus patients positive for antibodies to 60 kDa Ro. This initial epitope directly cross-reacts with a peptide from the latent viral protein Epstein-Barr virus nuclear antigen-1 (EBNA-1).


Immunizing animals with either the first epitope of 60 kDa Ro or the cross-reactive EBNA-1 epitope resulted in the animals progressively developing autoantibodies binding multiple epitopes of Ro and spliceosomal autoantigens, the authors write. Eventually, the animals acquire clinical symptoms of lupus such as leukopenia, thrombocytopenia and renal dysfunction. As a result, the authors conclude that some humoral autoimmunity in human lupus arises through molecular mimicry between EBNA-1 and lupus autoantigens, and they suspect that Epstein-Barr virus plays an etiologic role in SLE.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.