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Signal in noise: evaluating reported reproducibility of serum proteomic tests for ovarian cancer. Baggerly KA, Morris JS, Edmonson SR, Coombes KR, J Natl Cancer Inst. 2005 Feb 16;97(4):307-9.
In this report, the authors, at MD Anderson Cancer Center in
Baggerly says his group's analysis revealed that the pattern that enabled successful classification is biologically implausible and that the method, properly applied, does not classify the data accurately. The method used in previously published studies does not establish reproducibility and performs no better than chance for classifying the second dataset, in part because the second dataset is easy to classify correctly, the authors add. In conclusion, Baggerly says that the reproducibility of the proteomic profiling approach has yet to be established.