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Genome Library


Short Protocols in Human Genetics

Edited by: Nicholas Dracopoli, Jonathan Haines, Bruce Korf, Cynthia Morton, Anthony Rosenzweig, Christine Seidman, JG Seidman, and Douglas Smith

Published in November 2004, Short Protocols serves as a companion to Current Protocols in Human Genetics, also published by Wiley. This text provides abbreviated but precise lab methods ranging from basic science to clinical research. General topics include genetic mapping, genotyping, finding and identifying candidate genes, transcriptional profiling, and gene therapy, among others. The protocols are written clearly and with attention to detail; they cover both the old standbys as well as newer techniques, such as comparative genomic hybridization. — MS


Forensic DNA Typing
Biology, Technology, and Genetics of STR Markers, 2nd Edition

Written by: John M. Butler

Geared toward the forensic scientist, legal professional, and college student, Forensic DNA Typing offers a comprehensive look at the field of DNA applied to criminal forensics today, as well as the trends shaping the field’s development in the future. The author, a forensic scientist by training who helped develop the Short Tandem Repeat Internet Database while a postdoc at NIST, details the biology, technology, and genetics required to perform STR-based forensic science, and delves into new technology employing SNPs and Y chromosome testing. New additions to the second edition also include new DNA extraction procedures, real-time PCR for DNA quantification, and a discussion of statistical issues associated with data analysis and interpretation. — JSM


The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.