Skip to main content
Premium Trial:

Request an Annual Quote

Genome of Gluconobacter Oxydans Sequenced; Used to Make Vitamin C, Diabetic Drug

NEW YORK, Jan. 26 (GenomeWeb News) - Researchers from the Universityof Göttingenin Germanyand the Universityof Wisconsin-Milwaukeehave sequenced the genome of Gluconobacter oxydans, an industrially used acetic acid bacterium.

 

G. oxydans is used in the production of vitamin C, the antidiabetic drug Miglitol, flavoring chemicals, and other industrial products. It also serves as a sensor system for the detection of alcohols, sugars, and polyols. Naturally, the bacterium occurs on flowers and fruits. It is also found in spoiled wines, beers, and soft drinks, where it causes off-flavors. G. oxydans is able to incompletely oxidize a variety of carbohydrates and alcohols in a process called oxidative fermentation.

 

The genome of G. oxydans 621H, published online this week in Nature Biotechnology, consists of 2.7 million base pairs and contains 2,400 open reading frames. In addition, the bacterium possesses five plasmids with 232 open reading frames.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.