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General Eisenhower Would Be Proud

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University of Cambridge researchers have filmed killer T-cells as they attack cancer cells and transfer toxic enzymes to them via the centrosome, reports New Scientist. Researcher Gillian Griffiths tells New Scientist that this shows how powerful and accurate killer T-cells are. "You have to focus that secretion incredibly accurately and we found that the centrosome goes right up to the membrane at the point where the secretion is delivered to make that happen," she says. The researchers hope this work will help them find ways to exploit a patient's natural immunity in the fight against cancer.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.