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Gene Network Sciences, UCSD, Cornell Team Get $2M For Heart Modeling Project

NEW YORK, Feb. 5 (GenomeWeb News) -Gene Network Sciences, Cornell, and The University of California, San Diego have been awarded a $2 million bioengineering research grant from the National Heart, Lung, and Blood Institute to develop a computer model of the canine ventricle, the parties said today.


In the project, Robert Gilmour's lab at Cornell will initially characterize ionic currents of single heart cells, then a team at Ithaca, NY-based Gene Network Sciences led by Jeffrey Fox will construct computer models for the heart cells, and incorporate them into a 3-D computer model of a canine ventricle. Wouter-Jan Rappel of UCSD will then lead efforts to use the model to test candidate mechanisms for the development of ventricular fibrillation, as well as refine techniques to handle the computational demands of the project and contribute models of intracellular calcium dynamics.


"Our goal in creating the 3-D computer model is to better understand the underlying mechanisms for [ventricular fibrillation] and to eventually have a significant impact on the diagnosis and treatment of deadly heart rhythm disorders," Gilmour said.


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