As we watched one announcement after another of public funding for computational biology centers come out recently (see story, p. 11), it seemed like the time was ripe to take a look at some of the biggest grants NIH has awarded to the field. Here, we list grants that were issued between Jan. 1 and Sept. 15, 2005, that clearly support bioinformatics research. For the sake of space, we selected only the largest of the grants given out. This list is not comprehensive.