Skip to main content
Premium Trial:

Request an Annual Quote

Four years and a killer combo

Premium

Quick! Got a candle and a cupcake nearby? Well, even if you don’t, help us celebrate our birthday. Believe it or not, Genome Technology’s been around for four years with this issue. As someone who’s been here since the second issue of the magazine came out, I can truly say it is a privilege to be here with you. Thank you all for giving us such a fascinating field and vibrant community to cover.

Speaking of fascinating, take a look at this issue. Like the first genius to pair the unlikely combination of chocolate and peanut butter, scientists in integrated biology have taken the disparate technologies of RNA interference and microarrays and figured out how to make them produce some remarkable results together. Researchers are using these tools together to study off-target effects of RNAi, save money on gene screening experiments, and perform RNAi in a multiplexed, high-throughput fashion. Arrays won’t be the cure-all for the challenges facing RNAi, but they’re certainly making a dent, our experts told us. Check out that story to find out who’s doing what and how far along these technology pairings are.

Ever since the gauntlet was laid down challenging scientists to find innovative ways to cut sequencing costs drastically enough to sequence a human genome for $1,000, we’ve been avidly following the technologies that show some promise of getting there. Last year, we introduced you to 14 efforts underway. In this issue, we revisit the genome-for-a-grand race to bring you a status report. In short, that race is far from over — many experts are predicting five years or more before technology breaks that barrier. Senior Editor John MacNeil takes you on a tour of the field, which in the past year has done much to bring previously academic-only efforts closer to commercialization. There are some new technologies out there, and many of the old favorites are still on track to bring their tools to market.

As you know, next month we’ll be relaunching this magazine. For the most part, we’ll be the same magazine you’re familiar with. But we’ll have a fresh new look thanks to tremendous effort from our art team as well as some new content designed especially for scientists like you who need lots of information as quickly as possible. I’ll save the specifics for next month, but as a hint of what to look for in your mailbox come October, here’s what our new logo will look like. See you next month.

 

Meredith W. Salisbury, Editor

What do you think of Genome Technology? Let me know how we’re doing by e-mailing me at [email protected] or by calling me at +1.212.651.5635.

 

Coming in our October issue:

• Centers for integrative genomics: With two new Centers of Excellence in Genomic Science just announced by NHGRI, we’ll take you inside several CEGS to see how they’re doing with their mandate to perform innovative integrative genomics research. The centers’ niches include modeling signal transduction pathways; epigenetics; and new technology development, among others. How will these centers’ efforts help shape the future of genomics and systems biology?

• Quantitative protein analysis: There’s been a surge in the complexity and variety of tools designed to quantify and image which proteins are over- or under-expressed in disease tissue. We’ll look at where the technology has made significant strides, where it is still lacking, and how the data generated may ultimately be of value to life science research.

 

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.