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Focusing on 'Genomic Instability'

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Is it the chicken or the egg? "Genomic instability" is associated with the formation of cancer, but whether the instability drives tumor progression or is driven by it, is still unclear, says Nature Reviews Cancer. New findings show that certain DNA repair pathways and processes that control cell cycles all affect genomic stability and the development of cancer. Researchers are actively trying to manipulate these pathways and processes to see if they can induce tumor cell death, or target them with chemotherapeutic agents and other treatments, the journal adds. Nature Reviews Cancer has an ongoing series of studies on this topic that look into the field and examine the questions researchers are trying to answer and the progress they've made.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.