If you want to start a major argument among industrial drug discovery chemists, start talking about outsourcing. "It's working out great," some of them will say. "We can farm out all the boring methyl-ethyl- butyl-futile compounds, and just work on the interesting stuff here." "Well, that's just great for those of you who still have jobs," comes one answer, "but what about those of us who've been laid off during all those mergers?" And someone else may well join in by saying "And you know, not all that outsourced chemistry works out the way it's supposed to.