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Experimental Crystal Structure of SARS Posted to Protein Data Bank

NEW YORK, July 30 - Structural Genomix of San Diego today announced that it has deposited in the public protein data bank a three-dimensional crystal structure of the main protease from the coronavirus associated with SARS (Severe Acute Respiratory Syndrome).


SGX researchers used X-ray diffraction to determine a high-resolution, experimental structure of the SARS main protease, the company said in a statement.


The company said it is making the structure available through the database in advance of publishing its research in an unnamed scientific journal, and is exploring collaborations for treatment of the virus. The main protease is believed to be the primary target for inhibitory antiviral agents and the experimental determination of its crystal structure is part of the discovery process that could lead to new drugs to combat the virus.


The company said that it determined the structure of the protease in a month after receiving cDNA clones from the Genome Institute of Singapore.

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