Skip to main content
Premium Trial:

Request an Annual Quote

Experimental Crystal Structure of SARS Posted to Protein Data Bank

NEW YORK, July 30 - Structural Genomix of San Diego today announced that it has deposited in the public protein data bank a three-dimensional crystal structure of the main protease from the coronavirus associated with SARS (Severe Acute Respiratory Syndrome).

 

SGX researchers used X-ray diffraction to determine a high-resolution, experimental structure of the SARS main protease, the company said in a statement.

 

The company said it is making the structure available through the database in advance of publishing its research in an unnamed scientific journal, and is exploring collaborations for treatment of the virus. The main protease is believed to be the primary target for inhibitory antiviral agents and the experimental determination of its crystal structure is part of the discovery process that could lead to new drugs to combat the virus.

 

The company said that it determined the structure of the protease in a month after receiving cDNA clones from the Genome Institute of Singapore.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.