Electron Microscopy A Proteome in 3-D? Baumeister s Tomography Might Be the Key | GenomeWeb

Speaking to the assembled masses at the American Society for Cell Biology meeting last December, Wolfgang Baumeister presented an intriguing vision for the future of electron microscopy. What if, he asked, instead of capturing two-dimensional images of the inner workings of the cell — a format that compresses visual data into just one plane — one could create three-dimensional images of the cell’s entire proteome, while simultaneously identifying every protein in the image?

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