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DOE, JGI, and Stanford Sequence Human Chromosome 19

NEW YORK, April 2 (GenomeWeb News) - The US Department of Energy, the Joint Genome Institute, and Stanford University announced Wednesday that they have completed the sequencing of human chromosome 19. The sequence was described in the April 1 issue of Nature.

 

The sequence of the chromosome - which represents 2 percent of the genome's base pairs but contains almost 1,500 genes - is 500 times better in terms of contiguity and accuracy than previous draft human genome sequences, according to Stanford.

 

The DOE originally began the sequencing project in the 1990s because it contained DNA repair genes that could be useful in the agency's bid to study the link between DNA damage from radiation, and cancer. The project was transferred to the JGI and Stanford in 1999.

 

Among the genes encoded in chromosome 19 are genes for the diseases of insulin-dependent diabetes, myotonic dystrophy, migraines, and familial hypercholesterolemia.

 

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