Skip to main content
Premium Trial:

Request an Annual Quote

DNA Fingerprinting Extreme Extraction: Portable Igloos, Chilly Genomics Studies

Premium

At the bottom of the world, a handful of very cold researchers risked freezing their pipettes off trying to understand what makes some of the hardiest bugs on earth tick.

During a two-week mission to Antarctica’s Dry Valley, a desolate expanse of jagged rocks and frozen earth that occupies one of the few spaces on that continent not covered by ice, four scientists sought to study the few microorganisms that comfortably exist there.

The team, comprising scientists from the University of Western Cape Town, in South Africa, the University of Waikato, in New Zealand, and London’s University College, occupied a few tiny domed tents outfitted with a portable molecular lab that fits into a suitcase and weighs upwards of 40 pounds.

The goodies in that kit, made by MJ Research of Waltham, Mass., let the scientists perform DNA fingerprinting on microbes that live in a part of the world that last saw rain 4 million years ago. Data that they collect from their trip, they say, might help others to develop research tools that can stand up to such extreme temperatures. The kit allowed for DNA extraction, PCR with universal or selective primers, and electrophoresis, according to Craig Cary, a visiting professor at the University of Waikato and one of the Antarctica researchers.

The scientists performed their work as if they were in their own university labs — except that they usually sat crouched on frozen ground and operated their pipettes dressed in down windbreakers, snow pants, fleece balaclavas, and 10-pound insulated boots. Though it was the middle of the arctic summer, temperatures in the tents seldom broke zero degrees Celsius, more often hovering around -8.

“The only thing that I changed was we used an Invitrogen dry gel product for the electrophoresis, as the wet one that came with the unit would have frozen,” Cary says.

— Kirell Lakhman

 

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.