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A Difficult Cancer Elucidated

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A new study published by MD Anderson Cancer Center researchers in Cell Stem Cell describes a technique that can separate prostate cancer cells based on their levels of prostate-specific antigen, says an MD Anderson press release. Further, the team says its ability to separate low-PSA and high-PSA cells led to the discovery of a low-PSA population of cancer stem cells that seem to be important in the development of castration-resistant prostate cancer. "In cell lines and mouse model experiments, the low-PSA cells resisted chemotherapy and thrived under hormone deprivation," the release adds. "Low-PSA cells were found to be both self-renewing and capable of differentiating into other prostate cancer cell types upon division." These findings may help researchers develop new therapeutics specifically targeted to low-PSA cells.

The Scan

Follow-Up Data Requests to Biobank Participants Ineffective, Study Finds

An effort to recontact biobank enrollees for additional information reports low participation in a new BMJ Open study.

Study Finds Widespread Transmission of Resistant Bacteria in Vietnam Hospitals

A sequencing study in The Lancet Microbe finds widespread transmission of drug-resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii in two Vietnam ICUs.

Novel Brain Cell Organoids Show Promise for Autism Research

University of Utah researchers report in Nature Communications on their development of brain cell organoids to study SHANK3-related autism.

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.