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A Difficult Cancer Elucidated


A new study published by MD Anderson Cancer Center researchers in Cell Stem Cell describes a technique that can separate prostate cancer cells based on their levels of prostate-specific antigen, says an MD Anderson press release. Further, the team says its ability to separate low-PSA and high-PSA cells led to the discovery of a low-PSA population of cancer stem cells that seem to be important in the development of castration-resistant prostate cancer. "In cell lines and mouse model experiments, the low-PSA cells resisted chemotherapy and thrived under hormone deprivation," the release adds. "Low-PSA cells were found to be both self-renewing and capable of differentiating into other prostate cancer cell types upon division." These findings may help researchers develop new therapeutics specifically targeted to low-PSA cells.

The Scan

Push Toward Approval

The Wall Street Journal reports the US Food and Drug Administration is under pressure to grant full approval to SARS-CoV-2 vaccines.

Deer Exposure

About 40 percent of deer in a handful of US states carry antibodies to SARS-CoV-2, according to Nature News.

Millions But Not Enough

NPR reports the US is set to send 110 million SARS-CoV-2 vaccine doses abroad, but that billions are needed.

PNAS Papers on CRISPR-Edited Cancer Models, Multiple Sclerosis Neuroinflammation, Parasitic Wasps

In PNAS this week: gene-editing approach for developing cancer models, role of extracellular proteins in multiple sclerosis, and more.