Diagnosing the Unknown

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As a clinician, Gauri Varadharachary has seen quite a few patients with metastatic tumors for which no amount of tests or imaging could determine the primary tumor site. If after CT scans, PSA testing, mammograms, and more targeted testing, the site still remains elusive, then the patients are diagnosed with carcinoma of unknown primary and are often treated with systemic chemotherapy instead of targeted therapies. Varadharachary, though, is working to change that by developing molecular-based methods to determine the origin of these types of tumors.

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