Skip to main content
Premium Trial:

Request an Annual Quote

Definigen Joins European Stem Cell Bank Consortium

NEW YORK (GenomeWeb) – Stem cell products and services provider Definigen said today it will validate induced pluripotent stem cells for the European Bank for Induced Pluripotent Stem Cells (EBiSC) consortium.

EBiSC is a 26-partner public-private European initiative coordinated by Pfizer and managed by Roslin Cells that will store and distribute iPS cells to global research communities.

Cambridge, UK-based Definigen said it will validate the EBiSC cell lines by generating liver hepatocyte cells to be used in toxicology, disease modeling, and regenerative medicine applications.

The consortium launched in February 2014 with a €35 million ($46.2 million) commitment from the Europe's Innovative Medicine's Initiative, a €1 billion program created and funded by the members of the European Federation of Pharmaceutical Industries and Associations and the European Union.

The investment in the EBiSC consortium will fund the project's initial build-out of a robust, reliable, supply chain that includes the generation of customized cell lines, specification of internationally accepted quality criteria, and distribution to qualified users around the world.

There are currently many research programs underway in Europe that are producing iPS cells from hundreds of different donors. In the process, many extra cells are created that could be of use to other researchers. The driving vision behind the EBiSC consortium is to collect and store the extra iPS cells that were created for those specific research projects and distribute them to other scientists.

"The consortium includes many of Europe's leading stem cell scientists and experts in related fields, such as data management, law, and social sciences," Roslin Cells' Aidan Courtney said in a statement.

"We will keep abreast of the fast moving progress in the field of how to make these cells and also provide an online resource to pool the results of research undertaken with the catalogue of items that we distribute," Courtney added. "In this way, EBiSC will create an ever increasing wealth of iPS cells, data, and knowledge, which will help advance drug development and health research."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.