Skip to main content
Premium Trial:

Request an Annual Quote

CTI to Buy TGen-Affiliated PGx Drug Maker for At Least $20M

NEW YORK (GenomeWeb News) — Oncology products maker Cell Therapeutics has struck a deal to buy Systems Medicine, a pharmacogenomics-focused cancer drug company co-founded by Translational Genomics Research Institute’s physician-in-chief, Daniel Von Hoff, CTI said yesterday.
 
In a stock merger valued at around $20 million, with the potential for an extra $15 million more in milestone payments going to SMi stockholders, CTI intends to use “SMi’s strategic affiliation with TGen” to guide “clinical trials toward patient populations where the highest likelihood of success should be observed, thereby potentially lowering risk and shortening time to market.”
 
Tucson, Ariz.-based SMi focuses on using pharmacogenomic profiling to develop oncology drugs that target what it calls “the tenderloin” of patients that may benefit from a drug through clinical trials.  
 
Under the terms of the agreement, SMi will operate as a wholly owned subsidiary of CTI where it will use its genomic-based platform to guide development of CTI's oncology products.
 
Von Hoff, who is also director of the Clinical Translational Research Division at TGen and chief scientific officer of U.S. Oncology, is expected to head CTI's “strategic product portfolio committee.”
 
Richard Love, a founder of SMi and former founder and CEO of ILEX Oncology, is expected to join CTI's board.

According to a statement, SMi “applies a systems biology approach to drug development, combining pharmacogenomics and bioinformatics with experienced preclinical, clinical, and regulatory expertise to find and exploit a specific cancer's 'context-of-vulnerability.'”

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.