Skip to main content
Premium Trial:

Request an Annual Quote

Consortium Publishes Sequence of Human X Chromosome; Dog s and Master s Virtually Identical

NEW YORK, March 17 (GenomeWeb News) - An international research consortium has published the gene sequence of the human X chromosome in this week's Nature.

 

This sequence joins detailed annotations and analyses already published for chromosomes 5, 6, 7, 9, 10, 13, 14, 19, 20, 21, 22, and Y as part of the International Human Genome Project.

 

Lead researcher Mark Ross of the Wellcome Trust Sanger Institute and researchers from Baylor College of Medicine; Washington University School of Medicine, St. Louis; the Max Planck Institute for Molecular Genetics; the Institute of Molecular Biotechnology; and Applied Biosystems conducted the analysis that has determined 99.3 percent of the X chromosome's euchromatic sequence, and the existence of 1,098 genes, including 399 "new" genes and 99 cancer-testis antigen genes.

 

The research team also compared the chromosome to the genome sequences of a variety of other organisms, including dog, rat, mouse, and chicken. They found that the gene order of the human and dog X chromosomes were virtually identical.

 

By comparing gene order in the human and rodent sequences, the researchers found several segments had reshuffled in the rodent lineage, and a 9-million-base-pair region appears to have been deleted from the rodent chromosome after humans and rodents diverged from their common ancestor.

 

In the comparison of the human X chromosome to the sequence of the chicken, the researchers found that most of the genes on the short arm of the human X are found on chicken chromosome 1, and most of the genes on the long arm of the human X are found on chicken chromosome 4. These findings support the idea that mammalian X and Y chromosomes evolved from an "ordinary" ancestral pair of identical chromosomes.

The Scan

Driving Malaria-Carrying Mosquitoes Down

Researchers from the UK and Italy have tested a gene drive for mosquitoes to limit the spread of malaria, NPR reports.

Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.