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Consortium Completes HapMap; Database Describes More Than 1 Million SNP Markers

NEW YORK, Oct. 26 (GenomeWeb News) - The International HapMap Consortium published a catalog of human genetic variation as part of a complete human haplotype map, NHGRI said today.


In October 2002, the public-private project pledged to create a human HapMap within three years. The Phase I HapMap, which appears in the Oct. 27 issue of the journal Nature, describes more than 1 million SNP markers.


The Phase I HapMap is "three times more detailed than initially expected," said Francis Collins, NHGRI director who served as the project manager, at a press conference in Salt Lake City today.


The laboratory work for Phase II HapMap was completed this week, said Kelly Frazer of Perlegen Sciences at the press conference. Once the data analysis is completed, the Phase II HapMap will nearly triple the number of known markers.


Consortium researchers described ongoing research projects already taking advantage of the HapMap in studies. They predicted an "outpouring of discoveries" of gene variations for common diseases such as heart disease, diabetes, asthma, and hypertension in the next two to three years as a result of the HapMap.


All the HapMap data, like the data from the Human Genome Project, will be available in public databases.


A team of 200 researchers from six countries, including Canada, China, Japan, Nigeria, the United Kingdom, and the United States collaborated on the paper.

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