For most of the past 10 years, Michael Wolfe has been studying the biochemistry of gamma-secretase, painstakingly detailing its structure, function, and mechanism of action. The main culprits of Alzheimer's disease are short amyloid-beta peptides that build up and clump together in the brain. Gamma-secretase works alongside beta-secretase to cleave the amyloid precursor protein into its fatal, truncated cousin. Several years ago, Wolfe began characterizing beta-secretase, but this time with a new tack: determining how alternative RNA splicing affects the enzyme's function.

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Germany's Project DEAL has come to an agreement with the publisher Wiley over journal access and open-access publishing, ScienceInsider reports.

Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.

A Canadian panel recommends public coverage of the gene therapy Kymriah if its cost comes down, the Globe and Mail reports.

In Nucleic Acids Research this week: new accurate quantification by sequencing approach, CNV breakpoints in Plasmodium falciparum, and more.