A Complexity that Goes Beyond Genes | GenomeWeb

For most of the past 10 years, Michael Wolfe has been studying the biochemistry of gamma-secretase, painstakingly detailing its structure, function, and mechanism of action. The main culprits of Alzheimer's disease are short amyloid-beta peptides that build up and clump together in the brain. Gamma-secretase works alongside beta-secretase to cleave the amyloid precursor protein into its fatal, truncated cousin. Several years ago, Wolfe began characterizing beta-secretase, but this time with a new tack: determining how alternative RNA splicing affects the enzyme's function.

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The Wall Street Journal reports that National Institutes of Health Director Francis Collins' response to contamination concerns at the agency might have delayed care.

The final revision of the Common Rule doesn't include the proposed change requiring consent for leftover biospecimens.

The first Reproducibility Project: Cancer Biology papers show mixed results.

In Nature this week: mobile phone-based targeted DNA sequencing, and more.