For most of the past 10 years, Michael Wolfe has been studying the biochemistry of gamma-secretase, painstakingly detailing its structure, function, and mechanism of action. The main culprits of Alzheimer's disease are short amyloid-beta peptides that build up and clump together in the brain. Gamma-secretase works alongside beta-secretase to cleave the amyloid precursor protein into its fatal, truncated cousin. Several years ago, Wolfe began characterizing beta-secretase, but this time with a new tack: determining how alternative RNA splicing affects the enzyme's function.

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In a survey, about half of Canadian government scientists say they still feel as though they cannot speak freely, ScienceInsider reports.

Clinicians in China are moving ahead with a number of CRISPR trials, NPR reports, as the US embarks on its first.

The Atlantic reports that biohacker Josiah Zayner regrets injecting himself with the CRISPR gene-editing tool on stage.

In Nature this week: genomic approaches applied to study Neolithic and Bronze Age Europeans, and more.