For most of the past 10 years, Michael Wolfe has been studying the biochemistry of gamma-secretase, painstakingly detailing its structure, function, and mechanism of action. The main culprits of Alzheimer's disease are short amyloid-beta peptides that build up and clump together in the brain. Gamma-secretase works alongside beta-secretase to cleave the amyloid precursor protein into its fatal, truncated cousin. Several years ago, Wolfe began characterizing beta-secretase, but this time with a new tack: determining how alternative RNA splicing affects the enzyme's function.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.