Skip to main content
Premium Trial:

Request an Annual Quote

Clinical Data and Duke University to Collaborate on Statin PGx Research

NEW YORK, May 12 (GenomeWeb News) - Clinical Data announced today that it has entered into a five-year research collaboration agreement with the Institute for Genome Sciences & Policy at Duke University to discover genetic variants associated with baseline lipid parameters and the response of these parameters to statins.


Under terms of the agreement, Clinical Data's PGxHealth division will non-exclusively provide Duke with confidential access to its Strength studies, which involved evaluating the response of 679 patients to atorvastatin, pravastatin, simvastatin, lovastatin, and cerivastatin; genotopying approximately 175 genes; and evaluating 700 control patients at baseline. In return, Clinical Data will have the right to evaluate the commercial potential of any findings derived from Duke studies which used Strength clinical and/or genetic databases.


Duke researchers are planning a series to studies to find and validate associations between genetic variants and responses to drugs used for dyslipidemia, or hypercholesterolemia, Clinical Data said. The university is also planning on carrying out similar studies in the areas of hypertension and asthma.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.