Skip to main content
Premium Trial:

Request an Annual Quote

Ciphergen Applies its Protein Chip to Two AIDS Research Partnerships

NEW YORK, Feb. 14 - Scientists from two prestigious AIDS research lab will work with Ciphergen Biosystems in a pair of collaborations designed to profile immunological proteins in long-term non-progressors, a class of patient who have had HIV for decades but who have not developed AIDS.


In the first arrangement, a Collaborative Research and Development Agreement, immunologists from the US National Institute of Allergy and Infectious Disease will use Ciphergen's protein chips to profile non-cytolytic antiviral factors recently discovered in some HIV-positive patients.


Under the agreement, Ciphergen retains some commercial rights to the technology.


In a separate but similar Research and License Agreement, Rockefeller University's Aaron Diamond AIDS Research Center will use Ciphergen's protein chip system to probe other soluble factors secreted by the cytotoxic T cells found in long-term nonprogressors.


These proteins might be used directly as antiviral agents, or point the way to future drug targets, ADARC CEO David Ho said in a statement.


Ciphergen will have therapeutic and diagnostic rights to discoveries made in the collaboration, and ADARC will receive royalties on any commercializable products.


AIDS researchers have long been puzzled by long-term non-progressors, who represent a tiny fraction of the HIV-positive population. Immunologists hope that studying these patients may point the way to better treatments or an anti-HIV vaccine.


"Our technology is extremely good at differential protein analysis, where you might take a serum sample of an HIV-infected person, do a protein profile, and compare to a serum sample from someone with HIV who has not progressed," said Ciphergen Vice President and Chief Financial Officer Matthew Hogan. "Our platform can work extremely rapidly, and pick up different parts of the proteome than other techniques."


ADARC and Ciphergen researchers have already identified several candidate biomarkers with the Ciphergen ProteinChip system, and company researchers will continue to work the HIV scientists to fine-tune the expression profiling.


Ciphergen's ProteinChip systems is designed to allow researchers to identify protein biomarkers and biomarker patterns, making it useful in diagnostics and toxicology studies. The system is currently used by AstraZeneca, BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, and Pharmacia, among others.

The Scan

Guidelines for Ancient DNA Work

More than two dozen researchers have developed new ethical guidelines for conducting ancient DNA research, which they present in Nature.

And Cleared

A UK regulator has cleared former UK Prime Minister David Cameron in concerns he should have registered as a consultant-lobbyist for his work with Illumina, according to the Financial Times.

Suit Over Allegations

The Boston Globe reports that David Sabatini, who was placed on leave from MIT after allegations of sexual harassment, is suing his accuser, the Whitehead Institute, and the institute's director.

Nature Papers on Esophageal Cancer, Origin of Modern Horses, Exome Sequencing of UK Biobank Participants

In Nature this week: genetic and environmental influences of esophageal cancer, domestic horse origin traced to Western Eurasian steppes, and more.