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CHOP Genotypes 4,500 Samples for Autism Genetics Research

NEW YORK (GenomeWeb News) – The Children’s Hospital of Philadelphia said today it has contributed a set of genotype data to the Autism Genetic Resource Exchange, or AGRE, which it gained through analyzing 4,500 samples AGRE had gathered.
CHOP's Center for Applied Genomics performed the genotyping with an Illumina HumanHap550 system.
The samples used in the analysis came from 4,500 individuals from around 900 families, including 1,250 children with autism spectrum disorders, their parents, and their siblings.
AGRE is a program of the organization Autism Speaks, which will make the genetic dataset accessible to researchers worldwide, CHOP said.
University of Pennsylvania researcher Maja Bucan, who is a collaborator on the project, said the high-density genotype data will provide novel insights into the genomic landscape of autism as well as other neurodevelopmental disorders.

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