Skip to main content
Premium Trial:

Request an Annual Quote

Chinese SARS Researchers Use Supercomputers to Characterize Viral Proteins

NEW YORK, May 20 - Scientists in Chinaare using supercomputers and computational methods to identify key proteins of the coronavirus that causes SARS, Silicon Graphics said in an announcement today highlighting its role in the work.


Scientists at the Shanghai Institute of Materia Medica  (SIMM) have been working to analyze the SARS coronavirus genome ,and do protein predictions as well as alterations in proteins, then are construct ing3D models of proteins and virtually screen for compounds that may interact with this proteins.


SIMM has a 64-processor SGI Origin 3800, an additional four-processor SGI Origin 3200 server, and 15 SGI Graphics workstations for modeling and virtual screening of millions of structures.


The group at SIMM is using the supercomputer to map sites of mutation on the SARS coronavirus genome, and create datasets to characterize the structure of the mutant proteins encoded at these sites. Then, the researchers use the SGI graphics workstations to model these protein structures in three dimensions, SGI said.


Meanwhile, researchers at the Beijing Genomics Institute are working to sequence 100 isolates of the SARS virus for mutation studies. To model SARS-related protein sequences and key genome regions, Institute researchers are using two 32-processor SGI Origin 3000 supercomputers, a 5TB SGI TP9100 Fibre Channel storage system and several Silicon Graphics O2 graphics systems, the Mountain View, Calif., the company said.


GenomeWeb Coverage of SARS


Abbott Labs Will Help Artus Market, Distribute PCR-based SARS Test (May 15, 2003)

German Group Explores SARS Coronavirus Proteinase Structure (May 13, 2003)

///issues/news//121849-1.html"ONT-SIZE: 12pt; FILTER: ; MARGIN: 0in 0in 0pt; BOTTOM: 0px; FONT-FAMILY: 'Times New Roman'">Study Analyzes How SARS Virus Changed As It Spread Across the Globe (May 9, 2003)


CombiMatrix Develops siRNA to Target SARS Virus (May 7, 2003)

Affymetrix to Offer SARS GeneChip (May 6, 2003)

///issues/news//121849-1.html" (May 2, 2003)

Roche to Launch RT-PCR-based SARS Diagnostic by July (April 28, 2003)


CombiMatrix's Ali Arjomand on Developing a SARS Microarray ( ///issues/news//121849-1.html"tyle="FONT-SIZE: 10pt; COLOR: #040000">University of Manitoba Proteomics Researchers Tackle SARS Virus Proteins ( ///issues/news//121849-1.html">   (April 21, 2003)

Singapore Team Finishes SARS Virus Genome; Canadian Scientists Identify Viral Proteins  (April 17, 2003)

///issues/news//121849-1.html"">CombiMatrix Creates Microarray Based on SARS Genome Data   (April 16, 2003)

CDC Completes SARS Virus Genome Draft On Heels of Canadian Team  (April 14, 2003)


The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.