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Chicken Pox, Small Pox … Cancer?

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A team of researchers at Leeds University and the Mayo Clinic have published a new study in Nature Medicine, which suggests that they're close to developing a vaccine to shrink tumors, reports Reuters. The researchers' technique uses a cDNA library from organs in which tumors can form and spread, and early tests on mice with prostate cancer show that the vaccine could eventually be used in human cancer patients, Reuters says, though the team adds that human trials are years away. Several companies are trying to develop therapeutic vaccines — which are meant to treat a disease after it has formed, not prevent it as a traditional vaccine does — for different kinds of cancer. Where this vaccine differs is that because it contains a library of DNA with multiple genes, it could create many different antigens and fight several kinds of cancer, Reuters says.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.