Skip to main content
Premium Trial:

Request an Annual Quote

Cenix, IMM Develop RNAi Screen for Malaria; Seek Funding for Larger Assay

NEW YORK, June 29 (GenomeWeb News) - Researchers at the Instituto de Medicina Molecular in Lisbon, Portugal, and Cenix Bioscience hjave developed an RNAi screen for malaria genes that may lead to better anti-malarial therapeutics, the IMM and Cenix said in a statement.

 

The screen is based on an in vitro assay developed by Maria Mota's lab at the IMM that monitors the response of human liver cells to malaria infection. Dresden, Germany-based Cenix adapted Mota's assay for high-throughput RNAi screening, and a pilot study using the screen has been completed.

 

According to the two partners, a larger screen is now underway that "will cover over 800 human genes including all known kinases, key regulators of nearly all cellular pathways." They are also seeking additional funding to expand the capabilities of the assay, they said.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.