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Canadian, US, Chinese Teams Publish SARS Genome Sequence

NEW YORK, May 2 - Two research teams from Canada and the US published their studies of the genomic sequence of the SARS virus in Science yesterday, while a Beijing-based group published its study in the Chinese Science Bulletin.

 

The two American groups sequenced different strains of the virus, a new variety of coronavirus that causes severe acute respiratory syndrome. The sequences are similar but differ slightly in length. Both teams found several putative genes, including four encoding essential proteins that enable the virus to enter host cells and replicate, and five others encoding "non-essential" proteins. The Chinese researchers found six putative protein coding sequences and five uncharacterized ORFs.

 

 

While the SARS genome has the same overall structure as those of the three known classes of coronavirus, individual proteins differ in their predicted amino acid sequence.

 

GenomeWeb/Newsletters' coverage of SARS  

DeRisi Lab Uses its Viral Microarray To Help CDC Zero in on SARS Mystery  (BioArray News, April 4, 2003)

Canadian Team Sequencing SARS Virus   (Apr 9, 2003)
CDC Hails SARS Virus Sequencing, Discusses PCR Diagnostic Development    (Apr 14, 2003)

CDC Completes SARS Virus Genome Draft On Heels of Canadian Team   (April 14, 2003)

Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs   (April 15, 2003)
CombiMatrix Creates Microarray Based on SARS Genome Data   (April 16, 2003)
Coronavirus Linked to SARS: WHO (April 16, 2003) 

Singapore Genome Institute Joins SARS Sequencing Fray  (April 16, 2003)

Singapore Team Finishes SARS Virus Genome; Canadian Scientists Identify Viral Proteins  (April 17, 2003)

Beijing Group Publishes Four SARS Sequences from Mainland China, Claims To Have One-Hour SARS Test   (April 21, 2003)

University of Manitoba Proteomics Researchers Tackle SARS Virus Proteins (ProteoMonitor, April 21, 2003)
CombiMatrix to Provide its SARS Arrays Free to Select Governments, Academia (April 23, 2003)

CombiMatrix's Ali Arjomand on Developing a SARS Microarray (BioArray News, April 25, 2003)

NCID said to Launch PCR Test for SARS Next Week (SNPTech Reporter, April 25, 2003)

RNAi Roundup: Qiagen Offers RNAi Expertise to SARS Scientists; Antisense Beats RNAi to SARS Drug Starting Line...(April 25, 2003)

Roche to Launch RT-PCR-based SARS Diagnostic by July (April 28, 2003)

The Scan

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Treatment Costs May Not Coincide With R&D Investment, Study Suggests

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Sleep-Related Variants Show Low Penetrance in Large Population Analysis

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Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.