NEW YORK, May 2 - Two research teams from
The two American groups sequenced different strains of the virus, a new variety of coronavirus that causes severe acute respiratory syndrome. The sequences are similar but differ slightly in length. Both teams found several putative genes, including four encoding essential proteins that enable the virus to enter host cells and replicate, and five others encoding "non-essential" proteins. The Chinese researchers found six putative protein coding sequences and five uncharacterized ORFs.
While the SARS genome has the same overall structure as those of the three known classes of coronavirus, individual proteins differ in their predicted amino acid sequence.
GenomeWeb/Newsletters' coverage of SARS
Canadian Team Sequencing SARS Virus (Apr 9, 2003)
CDC Hails SARS Virus Sequencing, Discusses PCR Diagnostic Development (Apr 14, 2003)
CDC Completes SARS Virus Genome Draft On Heels of Canadian Team (April 14, 2003)
Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs (April 15, 2003)
CombiMatrix Creates Microarray Based on SARS Genome Data (April 16, 2003)
Coronavirus Linked to SARS: WHO (April 16, 2003)
Singapore Genome Institute Joins SARS Sequencing Fray (April 16, 2003)
CombiMatrix's Ali Arjomand on Developing a SARS Microarray (BioArray News, April 25, 2003)
Roche to Launch RT-PCR-based SARS Diagnostic by July (April 28, 2003)