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Broad Institute to Use Affymetrix Arrays In Three Genomics Projects

NEW YORK, Sept. 22 (GenomeWeb News) - The Broad Institute of MIT and Harvard will use high-throughput microarray technology from Affymetrix in three studies involving RNA expression analysis, SNP genotyping, and DNA resequencing, Affymetrix said today.


In a genotyping study, researchers at the Broad Institute plan to use GeneChip SNP genotyping arrays to identify genes associated with common complex diseases. Affymetrix said it will make the arrays, which are based on the technology of its current Mapping 10K and Mapping 100K arrays, broadly available.


The institute's researchers also plan to conduct whole-genome RNA expression studies of several thousand samples, using GeneChip microarrays, and to assemble the results into a gene expression database of different physiological and disease conditions.


Finally, Broad Institute scientists plan to discover DNA sequence variations in cancer samples using CustomSeq resequencing arrays. They will also collaborate with Affymetrix to develop algorithms for automated sequence analysis.

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