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Blueprint Releases Initial Assembly Data Into Entrez Gene, Partners With NCBI, NLM

NEW YORK, June 8 (GenomeWeb News) - The Blueprint Initiative Asia, together with the National Center for Biotechnology Information, and National Library of Medicine has released an "initial" set of molecular assembly data to the Entrez Gene database from its Biomolecular Interaction Network, or BIND, database, the group said today.


"Our collaboration with NCBI and NLM is consistent with Blueprint's goal of facilitating basic and applied research by offering scientists a complete package of relevant information about important biological targets," Christopher Hogue, Blueprint project leader and principal investigator.


Terms of the agreement call for Blueprint to provide NCBI with a steady supply of BIND data for insertion into Entrez Gene. In exchange, Entrez Gene records will provide researchers with links back to the appropriate data entry in BIND. "The presence of interaction-focused BIND data at Entrez Gene will provide valuable molecular function information to many scientists who use Entrez Gene," the group said.


Linking to BIND from these records will also allow "ready access to fully annotated interaction data. The interaction data in Entrez Gene links researchers with Entrez Gene, Entrez Protein, and PubMed records of biomolecular partners, as well as to the deeply curated and structured records found within the BIND repository itself," Blueprint said.


An initial set of more than 10,000 BIND records have gone live on Entrez Gene, it added. These records provide information about more than 6,000 genes across more than 100 types of organisms.


Entrez Gene provides descriptions of experimental findings from scientific publications. This data could enable researchers to search and view detailed information about a gene on the basis of information such as gene names, accession numbers, symbols, publications, and chromosome numbers, Blueprint said.


The BIND database was designed to provides scientists with "highly structured and deeply curated" biological assembly data ranging from molecular interactions and small-molecule chemical reactions to interfaces from three-dimensional structures, pathways, and genetics interaction networks, also "largely" derived from peer-reviewed literature.


Until now, most functional annotation distributed from Entrez Gene has been extracted from "current" biomedical literature by employees of the Index Section of the NLM. BIND "enhances" this effort because its data are "attached to interacting molecules, and to sequences that define them."

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