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Biomagnets — How Do They Work?


Creating effective therapies for cancer is only step one of treating the disease. Step two involves finding a way to deliver those therapies where they can do the most good against tumor cells while leaving as many healthy cells alone as possible. Oklahoma-based biotech firm Nanobiomagnetics is working in collaboration with researchers at the MD Anderson Cancer Center on a new targeted chemotherapy delivery system that is meant to do exactly that, reports NewsOK's Paula Burkes. The company has combined magnetic nanoparticles of iron oxide with the breast cancer drug paclitaxel, and then, in mice, the MD Anderson researchers used external magnets to direct the drug to the tumor to halt its growth, Burkes says. "Here's how it works: As nanoparticles in the bloodstream near and — under force from external magnets — are attracted into the tumor, they release therapeutics that kill the tumor from the inside. But when the particles aren't near the tumor, they have no bioactivity or toxicity, so they'll float through the bloodstream until cleared by the kidneys," she adds. This delivery system is small and forceful enough to get past a tumor's defenses and deliver five times the conventional dose of chemotherapy. Pending FDA approval, the company hopes to start clinical trials within two years.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.