The April 2006 cover story looked at the state of high-throughput imaging as the next great discovery tool in systems biology. The story featured leading vendors and institutes, including the Whitehead Institute at MIT, Cellomics, and GE Healthcare’s bioscience unit. Advances continue — with an increasing emphasis on live cell imaging, speed and sensitivity are becoming most important.

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Researchers have found that the i-motif shape of DNA previously observed in the lab also exists in human cells, and that it may serve a purpose.

In PNAS this week: a genomic, transcriptomic, and metabolomic analysis of the tea plant, Arabidopsis thaliana's adaptations to specific local environments, and more.

In an against-all-odds twist, a researcher studying exceeding rare FOXG1 mutations discovers her daughter has the syndrome.

An effort by Genomics Medicine Ireland is creating a database of diseases based on the genomics of people in Ireland. It now is looking into the possibility of including Scotland in its work.