Beyond the Genome: Using Genomics to Improve Oncology | GenomeWeb

At the Beyond the Genome conference in Washington, DC, this week, Matthew Ellis from Washington University in St. Louis discussed his approach of "genome-forward oncology," which aims to extract maximum medical benefit from next-generation sequencing. When performing sequencing studies to discover something new about disease, it's necessary to do it within trials with excellent clinical annotation and under sample-rich conditions, Ellis said. Further when mutations are discovered, they need to be associated with clinically important phenotypes like drug resistance or disease relapse.

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