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AxCell and Celgene Collaborate on Ubiquitin Ligases

NEW YORK, Jan. 22-Cytogen subsidiary AxCell Biosciences will collaborate with Celgene to study the role of ubiquitin ligases in cancer and inflammation, Cytogen said today.

 

The two companies will investigate these compounds, which tag excess or damaged proteins for degradation, as potential treatments for cancer and inflammatory disease.

 

Financial specifics of the research collaboration were not disclosed.

 

Celgene has a portfolio of previously unknown ubiquitin ligases, and is studying small molecule regulators of these molecules.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.