As you’ll read in this issue, midsize sequencing facilities are trying to figure out how to keep themselves relevant, and Amersham Biosciences is trying to figure out how to keep its customers happy. New NHGRI funding policies and current biopharma spending patterns have served to heighten the need for re-examining goals, but in an industry that’s evolving and changing as quickly as this one, organizations need to stay in a constant state of self-scrutiny just to keep up. Genome Technology is no exception.