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APBiotech Introduces Flexible DNA Analysis Platform

NEW YORK, Dec 13 - Amersham Pharmacia Biotech has introduced a new high-performance multiple capillary DNA analysis system, the company announced Wednesday.

The new MegaBACE 500 system builds on technology developed for the company’s MegaBACE 1000 system, its first commercially available multiple capillary sequencer.

According to APBiotech spokeswoman Marcy Saack, the MegaBACE 500 system can flexibly  handle numerous different research tasks. “It’s easy to switch between sequencing and genotyping functions just by switching chemistry sets and software,” she said. In addition, the 48-capillary system can be upgraded to the 96-capillary MegaBACE 1000.

The system, which uses high-sensitivity confocal scanning optics and high-resolution capillary electrophoresis, can run 240 sequencing reactions in eight hours and 528 reactions in 24 hours.

By adding the SNuPe reagent kit and software, the MegaBACE 500 can determine up to 2880 SNPs in eight hours and 7680 SNPs in 24 hours.

According to the company, the system provides a significant throughput advantage in both genotyping and sequencing over competing systems that offer just16 capillaries.

" The needs of research institutions and pharmaceutical companies are constantly changing and increasing," Mark Sutherland, vice president of genomics at AP Biotech, said in a statement. " With the introduction of the MegaBACE 500, researchers will have a system that can evolve as their throughput requirements change and additional applications become important to the goals of the laboratory."

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